Part of the strength of good dialogue is there are so many ways it can be played. (Actors will surprise you.) The preceding lines are important.
Give me mine armor
How does your patient doctor
Not so sick, my lord, as she is with troubled with thick-coming fancies that keep her from rest
Cure [her] of that
Canst though not minister to a mind diseased
Actors need to be able to connect to the material, and the Doctor could be describing PTSD. Macbeth's response could be desperation, or it could be sarcastic. (Important to keep in mind that Macbeth is busy preparing for battle—having an activity not related to the dialogue is a huge boon performance-wise— so don't overlook a certain frenetic energy to the scene, as the play drives toward conclusion.) The physicians' art at the time was highly unreliable, so there may be skepticism similar to that often directed toward certain branches of psychology.
- Macbeth asks the doctor if he has a cure. The Doctor says in these cases only the patient themself has the cure. Macbeth says "To hell with you then. I'll have none of it."
It is a kind of "throw away", though, so I wouldn't over-emphasize. Note that the action of preparing for battle bookends the exchange.
Throw physick to the dogs—I'll have none of it
Come, put my armor on. Give me my staff.
What makes it work so well is that Macbeth is otherwise occupied. But it can get deeper.
A good technique for playwrights and actors both is "what does a character want? what do they really want? what do they really, really want?" So Macbeth may be keeping himself distracted to avoid dealing with his emotions. (His wife is descending into madness and that has got to bring up some heavy feelings. Note how many times the word "fear" is used in the scene. Dread would be a good word for what Macbeth is avoiding.)
Likewise there are many ways the second exchange between Macbeth and the Doctor could be played.
If thou couldst Doctor, cast the water of my land— find her disease
and purge it to a sound an pristine health,
I would applaud thee to the very echo that should applaud again
Pull it off, I say— what rhubarb, senna or what purgative drug
Would scour these English hence? Hearest thou of them?
Aye my good lord
Your royal preparations makes us hear something
The doctor's response is wry.
The question is, is Macbeth merely showing a stiff upper lip, good cheer in the face of imminent mortal danger, or is he losing his mind? (i.e. is he seriously asking the Doctor if he can scour the English from the land?)
The final line of the scene implies that the Doctor, at least, thinks Macbeth is a bit "off his rocker":
Were I from Dunsinane away and clear
Profit again should hardly draw me near.
Essentially, the Doctor is saying, "get me out of this madhouse." "If I had it to do over again, I wouldn't. I don't care how much you pay me."
Macbeth, Act V, Scene 2, line 42 ff. (Folger Library)
It does occur to me that if you did want to integrate some action to support the lines, you could have the Doctor trying to tend to Macbeth. (Perhaps he has "the shakes", or is experiencing some phantom ailment.)
They are talking about Lady Macbeth, and when the Doctor reveals he has no treatment that can heal her, Macbeth waves the Doctor off from ministering to him, having concluded that "physicking" is fruitless.
Specifically, both Macbeth and Lady M are suffering from PTSD.
Now the line is literal—Macbeth saying he have none of it in regard to himself. (There is the added dimension that he might realize his own ailment is mental, and therefore immune to treatment.)
This would also increase the kinetics of the scene because now you have Macbeth preparing for battle, being ministered to, and engaging in a diagnostic discussion all at once.